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The following text contains information regarding the methods of preventing illness and selfcare while coping with it. It is to be used responsibly. The following procedures cannot supplement professional medical treatment and healing in case of health issues.

The text is not to be reproduced in any way without the written consent of the authors.

FOREWORD

With the beginning of the new millennium, mankind has entered a realm ruled by stress, anxiety and other similar issues yet unknown to the human mind. These issues, often tied to the overwhelming amount of information we tend to receive daily, leave consequences both on our nervous and immune systems. Despite the amazing medical breakthroughs of the past century, we simply cannot function without nature. Nature is the only constant presence in our lives and since we are born from it, it is only fair to at least try to acquire a certain amount of knowledge about its secrets.

Cannabis is perhaps the most perfect example of man’s dependence on nature; throughout history (leaving out the last two unfortunate centuries, when the prohibition of cannabis creates an ever-greater gap between man and nature), it has provided him with just about everything – it was the key ingredient of clothes, ropes, food, medicine, paper and other necessities of everyday life.

Due to the massive amount of unreliable information on cannabis circling the wide web, we wish to gather some key facts on its effect on human life, which can become more centered and relaxed with its prudent use.

SOURCES: 

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Abrams DI., Guzman M., Cannabis in cancer care, Clin. Pharmacol. Ther. 2015, 97, pp. 575-86.

Ahmed A., van der Marck MA., van der ELSEN G., Cannabinoids in late – onset Alzheimer’s disease, Clin. Pharmacol. Ther. 2015, 97, pp. 597-606.

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Lintzeris, N., Bhardwaj, A., Mills, L., Dunlop, A., Copeland, J., McGregor, I., … & Allsop, D. (2019). Nabiximols for the treatment of cannabis dependence: a randomized clinical trial. JAMA internal medicine179(9), 1242-1253.

Dennis, M., Godley, S. H., Diamond, G., Tims, F. M., Babor, T., Donaldson, J., … & Funk, R. (2004). The Cannabis Youth Treatment (CYT) Study: main findings from two randomized trials. Journal of substance abuse treatment27(3), 197-213.

Naftali, T., Lev, L. B., Yablecovitch, D., Half, E., & Konikoff, F. M. (2011). Treatment of Crohn’s disease with cannabis: an observational study. The Israel Medical Association journal: IMAJ13(8), 455-458.

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M Weinstein, A., & A Gorelick, D. (2011). Pharmacological treatment of cannabis dependence. Current pharmaceutical design17(14), 1351-1358.

Gaston, T. E., & Szaflarski, J. P. (2018). Cannabis for the treatment of epilepsy: an update. Current neurology and neuroscience reports18(11), 1-9.

Abuhasira, R., Schleider, L. B. L., Mechoulam, R., & Novack, V. (2018). Epidemiological characteristics, safety and efficacy of medical cannabis in the elderly. European journal of internal medicine49, 44-50.

Kafil, T. S., Nguyen, T. M., MacDonald, J. K., & Chande, N. (2018). Cannabis for the treatment of Crohn’s disease. Cochrane Database of Systematic Reviews, (11).

Habib, G., & Artul, S. (2018). Medical cannabis for the treatment of fibromyalgia. JCR: Journal of Clinical Rheumatology24(5), 255-258.

Scherma, M., Masia, P., Deidda, M., Fratta, W., Tanda, G., & Fadda, P. (2018). New perspectives on the use of cannabis in the treatment of psychiatric disorders. Medicines5(4), 107.

Kafil, T. S., Nguyen, T. M., MacDonald, J. K., & Chande, N. (2018). Cannabis for the treatment of ulcerative colitis. Cochrane Database of Systematic Reviews, (11).

Lucas, P. (2012). Cannabis as an adjunct to or substitute for opiates in the treatment of chronic pain. Journal of psychoactive drugs44(2), 125-133.

Hoch, E., Niemann, D., von Keller, R., Schneider, M., Friemel, C. M., Preuss, U. W., … & Pogarell, O. (2019). How effective and safe is medical cannabis as a treatment of mental disorders? A systematic review. European archives of psychiatry and clinical neuroscience269(1), 87-105.

MacCallum, C. A., & Russo, E. B. (2018). Practical considerations in medical cannabis administration and dosing. European journal of internal medicine49, 12-19.

Agarwal, R., Burke, S. L., & Maddux, M. (2019). Current state of evidence of cannabis utilization for treatment of autism spectrum disorders. BMC psychiatry19(1), 1-10.

Dennis, M., Titus, J. C., Diamond, G., Donaldson, J., Godley, S. H., Tims, F. M., … & CYT Steering Committee. (2002). The Cannabis Youth Treatment (CYT) experiment: rationale, study design and analysis plans. Addiction97, 16-34.

Blake, D. R., Robson, P., Ho, M., Jubb, R. W., & McCabe, C. S. (2006). Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis. Rheumatology45(1), 50-52.

Copeland, J., & Maxwell, J. C. (2007). Cannabis treatment outcomes among legally coerced and non-coerced adults. BMC Public Health7(1), 1-7.

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Campbell, G., Stockings, E., & Nielsen, S. (2019). Understanding the evidence for medical cannabis and cannabis-based medicines for the treatment of chronic non-cancer pain. European archives of psychiatry and clinical neuroscience269(1), 135-144.

Miller, R. J., & Miller, R. E. (2017). Is cannabis an effective treatment for joint pain. Clin Exp Rheumatol35(5), 59-67.

Press, C. A., Knupp, K. G., & Chapman, K. E. (2015). Parental reporting of response to oral cannabis extracts for treatment of refractory epilepsy. Epilepsy & Behavior45, 49-52.

Haroutounian, S., Ratz, Y., Ginosar, Y., Furmanov, K., Saifi, F., Meidan, R., & Davidson, E. (2016). The effect of medicinal cannabis on pain and quality-of-life outcomes in chronic pain. The Clinical journal of pain32(12), 1036-1043.

Russo, E. B. (2017). Cannabis and epilepsy: an ancient treatment returns to the fore. Epilepsy & Behavior70, 292-297.

Porter, B. E., & Jacobson, C. (2013). Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy. Epilepsy & Behavior29(3), 574-577.

Aggarwal, S. K., Carter, G. T., Sullivan, M. D., ZumBrunnen, C., Morrill, R., & Mayer, J. D. (2009). Characteristics of patients with chronic pain accessing treatment with medical cannabis in Washington State. Journal of Opioid Management5(5), 257-286.

Mechoulam, R. (2012, February). Cannabis—a valuable drug that deserves better treatment. In Mayo Clinic Proceedings (Vol. 87, No. 2, pp. 107-109). Elsevier.

Hausman-Kedem, M., Menascu, S., & Kramer, U. (2018). Efficacy of CBD-enriched medical cannabis for treatment of refractory epilepsy in children and adolescents–An observational, longitudinal study. Brain and Development40(7), 544-551.

Lakhan, S. E., & Rowland, M. (2009). Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review. BMC neurology9(1), 1-6.

Berman, P., Sulimani, L., Gelfand, A., Amsalem, K., Lewitus, G. M., & Meiri, D. (2020). Cannabinoidomics–An analytical approach to understand the effect of medical Cannabis treatment on the endocannabinoid metabolome. Talanta219, 121336.

Babson, K. A., & Bonn-Miller, M. O. (2014). Sleep disturbances: Implications for cannabis use, cannabis use cessation, and cannabis use treatment. Current Addiction Reports1(2), 109-114.

Schleider, L. B. L., Mechoulam, R., Lederman, V., Hilou, M., Lencovsky, O., Betzalel, O., … & Novack, V. (2018). Prospective analysis of safety and efficacy of medical cannabis in large, unselected population of patients with cancer. European journal of internal medicine49, 37-43.